|chemokine (C-C motif) ligand 5|
The structure of human RANTES
|Alt. symbols||D17S136E, SCYA5|
|Locus||Chr. 17 q11.2-q12|
Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-γ) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.
- Maghazachi et al, CC chemokines induce the generation of killer cells from CD56+ cells, Eur J Immunol. 1996, 26:315-9.
- Donlon et al. Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12. Genomics 5: 548-553, 1990.
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