Protein N-acetylglucosaminyltransferase

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In enzymology, a protein N-acetylglucosaminyltransferase (EC is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + protein UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and protein, whereas its two products are UDP and 4-N-(N-acetyl-D-glucosaminyl)-protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase. Other names in common use include uridine diphosphoacetylglucosamine-protein, acetylglucosaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide, beta-N-acetylglucosaminyltransferase, and O-GlcNAc transferase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Khalkhall Z, Marshall RD (1975). "Glycosylation of ribonuclease A catalysed by rabbit liver extracts". Biochem. J. 146: 299&ndash, 307. PMID 1156375.
  • Khalkhali Z, Marshall RD (1976). "UDP-N-acetyl-D-glucosamine-asparagine sequon N-acetyl-beta-D-glucosaminyl-transferase-activity in human serum". Carbohydr. Res. 49: 455&ndash, 73. PMID 986874.
  • Khalkhali Z, Marshall RD, Reuvers F, Habets-Willems C, Boer P (1976). "Glycosylation in vitro of an asparagine sequon catalysed by preparations of yeast cell membranes". Biochem. J. 160: 37&ndash, 41. PMID 795426.

External links

The CAS registry number for this enzyme class is 72319-34-7.

Gene Ontology (GO) codes