Polymorphous light eruption

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Polymorphous light eruption
ICD-10 L56.4
ICD-9 692.72
DiseasesDB 10327
eMedicine derm/342 

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Polymorphous light eruption (PLE), or polymorphic light eruption, is a skin complaint caused by sunlight. Symptoms include skin irritations, which may be itchy or painful, and are sometimes confused with hives. These irritations appear upon exposure to sunlight—sometimes as little as 15 minutes of exposure to the sun can bring onset of the condition—and may last from 1 to 7 days. Generally, PLE resolves without treatment; also, PLE irritations generally leave no scar. The cases of this condition are most common between the spring and autumn months in the northern hemisphere.

Typically, 10-20% of the population are affected. It is more common in females than in males. The condition can affect all ethnic groups and research suggests that 20% of patients have a family history of the complaint. Those suffering from PMLE usually do so by age 30.

The cause of PLE is not yet understood. It is thought to be due to a type IV delayed-type hypersensitivity reaction.

Diagnosis

Physical Examination

Skin

Trunk
Ear
Face

Experimental treatments

As of 2008 a company in Australia named Clinuvel Pharmaceuticals Limited is performing clinical trials with a melanocyte-stimulating hormone named melanotan (which they refer to as CUV1647) for polymorphous light eruption.[2]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Dermatology Atlas".
  2. http://www.clinuvel.com/en/faqs/

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| group5 = Clinical Trials Involving Polymorphous light eruption | list5 = Ongoing Trials on Polymorphous light eruption at Clinical Trials.govTrial results on Polymorphous light eruptionClinical Trials on Polymorphous light eruption at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Polymorphous light eruption | list6 = US National Guidelines Clearinghouse on Polymorphous light eruptionNICE Guidance on Polymorphous light eruptionNHS PRODIGY GuidanceFDA on Polymorphous light eruptionCDC on Polymorphous light eruption


| group7 = Textbook Information on Polymorphous light eruption | list7 = Books and Textbook Information on Polymorphous light eruption


| group8 = Pharmacology Resources on Polymorphous light eruption | list8 = AND (Dose)}} Dosing of Polymorphous light eruptionAND (drug interactions)}} Drug interactions with Polymorphous light eruptionAND (side effects)}} Side effects of Polymorphous light eruptionAND (Allergy)}} Allergic reactions to Polymorphous light eruptionAND (overdose)}} Overdose information on Polymorphous light eruptionAND (carcinogenicity)}} Carcinogenicity information on Polymorphous light eruptionAND (pregnancy)}} Polymorphous light eruption in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Polymorphous light eruption


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Polymorphous light eruption | list9 = AND (pharmacogenomics)}} Genetics of Polymorphous light eruptionAND (pharmacogenomics)}} Pharmacogenomics of Polymorphous light eruptionAND (proteomics)}} Proteomics of Polymorphous light eruption


| group10 = Newstories on Polymorphous light eruption | list10 = Polymorphous light eruption in the newsBe alerted to news on Polymorphous light eruptionNews trends on Polymorphous light eruption


| group11 = Commentary on Polymorphous light eruption | list11 = Blogs on Polymorphous light eruption

| group12 = Patient Resources on Polymorphous light eruption | list12 = Patient resources on Polymorphous light eruptionDiscussion groups on Polymorphous light eruptionPatient Handouts on Polymorphous light eruptionDirections to Hospitals Treating Polymorphous light eruptionRisk calculators and risk factors for Polymorphous light eruption


| group13 = Healthcare Provider Resources on Polymorphous light eruption | list13 = Symptoms of Polymorphous light eruptionCauses & Risk Factors for Polymorphous light eruptionDiagnostic studies for Polymorphous light eruptionTreatment of Polymorphous light eruption

| group14 = Continuing Medical Education (CME) Programs on Polymorphous light eruption | list14 = CME Programs on Polymorphous light eruption

| group15 = International Resources on Polymorphous light eruption | list15 = Polymorphous light eruption en EspanolPolymorphous light eruption en Francais

| group16 = Business Resources on Polymorphous light eruption | list16 = Polymorphous light eruption in the MarketplacePatents on Polymorphous light eruption

| group17 = Informatics Resources on Polymorphous light eruption | list17 = List of terms related to Polymorphous light eruption


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