Phosphotransferase
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Phosphotransferases are a category of enzymes (EC number 2.7) which catalyze phosphorylation reactions. The general form is:
A—P + B ⇔ B—P + A
Where P is a phosphate group and A and B are the donating and accepting molecules, respectively.
Phosphostransferasesystem
This system is used by, for example, bacterias, to transport sugar (Glucose) into the cell. It is rather complex, and the first step of this reaction adds a Phosphor to the Glucose (via Phosphotransferase), producing Glucose-6-Phosphate. Due to the negative current of the Phosphate, this Glu6P can no longer freely leave the cell, and it is additionally the first reaction of Glycolysis (which will degrade the sugar to Pyruvate)
External links
Proteins: enzymes | |
|---|---|
| Topics | Active site - Allosteric regulation - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - Cooperativity - EC number Enzyme catalysis - Enzyme inhibitor - Enzyme kinetics - Lineweaver-Burk plot - Michaelis-Menten kinetics - List of enzymes |
| Types | EC1 Oxidoreductases/list - EC2 Transferases/list - EC3 Hydrolases/list - EC4 Lyases/list - EC5 Isomerases/list - EC6 Ligases/list |
Phosphotransferases/kinases (EC 2.7) | |
|---|---|
| 2.7.1 - OH acceptor | Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Thymidine - NAD+ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine |
| 2.7.2 - COOH acceptor | Phosphoglycerate - Aspartate |
| 2.7.3 - N acceptor | Creatine |
| 2.7.4 - PO4 acceptor | Phosphomevalonate - Adenylate - Nucleoside-diphosphate |
| 2.7.6 - P2O7 | Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase |
| 2.7.7 - nucleotidyl- | Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase |
| 2.7.8 - other phos. | N-acetylglucosamine-1-phosphate transferase |
| 2.7.10-11 - protein | Tyrosine - Serine/threonine-specific |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
