Phosphopentomutase

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In enzymology, a phosphopentomutase (EC 5.4.2.7) is an enzyme that catalyzes the chemical reaction

alpha-D-ribose 1-phosphate D-ribose 5-phosphate

Hence, this enzyme has one substrate, alpha-D-ribose 1-phosphate, and one product, D-ribose 5-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-ribose 1,5-phosphomutase. Other names in common use include phosphodeoxyribomutase, deoxyribose phosphomutase, deoxyribomutase, phosphoribomutase, alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate, phosphotransferase, and D-ribose 1,5-phosphomutase. This enzyme participates in pentose phosphate pathway and purine metabolism. It has 3 cofactors: D-ribose 1,5-bisphosphate, alpha-D-Glucose 1,6-bisphosphate, and 2-Deoxy-D-ribose 1,5-bisphosphate.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I09.

References

  • IUBMB entry for 5.4.2.7
  • BRENDA references for 5.4.2.7 (Recommended.)
  • PubMed references for 5.4.2.7
  • PubMed Central references for 5.4.2.7
  • Google Scholar references for 5.4.2.7
  • Hammer-Jespersen K, Munch-Petersen A (1970). "Phosphodeoxyribomutase from Escherichia coli. Purification and some properties". Eur. J. Biochem. 17: 397&ndash, 407. PMID 4992818.
  • Kammen HO, Koo R (1969). "Phosphopentomutases. I. Identification of two activities in rabbit tissues". J. Biol. Chem. 244: 4888&ndash, 93. PMID 5824563.
  • Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.

External links

The CAS registry number for this enzyme class is 9026-77-1.

Gene Ontology (GO) codes


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