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In enzymology, a peptide-O-fucosyltransferase (EC is an enzyme that catalyzes the chemical reaction in which an alpha-L-fucosyl residue is transferred from GDP-beta-L-fucose to the sidechain oxygen atom of a serine or threonine residue in a protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase. Other names in common use include GDP-L-fucose:polypeptide fucosyltransferase, GDP-fucose protein O-fucosyltransferase, and GDP-fucose:polypeptide fucosyltransferase.


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  • Wang Y, Spellman MW (1998). "Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells". J. Biol. Chem. 273: 8112&ndash, 8. PMID 9525914.
  • Haltiwanger RS (2001). "Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase". J. Biol. Chem. 276: 40338&ndash, 45. PMID 11524432.
  • Wang Y, Lee GF, Kelley RF, Spellman MW (1996). "Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains". Glycobiology. 6: 837&ndash, 42. PMID 9023546.
  • Peter-Katalinic J (2001). "C-mannosylation and O-fucosylation of the thrombospondin type 1 module". J. Biol. Chem. 276: 6485&ndash, 98. PMID 11067851.

External links

The CAS registry number for this enzyme class is 9033-08-3.

Gene Ontology (GO) codes