Paroxysmal cold hemoglobinuria causes

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Paroxysmal cold hemoglobinuria Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Luke Rusowicz-Orazem, B.S.

Overview

PCH can be an after effect of an infection, when a microorganism triggers the formation of antibodies that cross-react with the P antigen on the red blood cell membrane. Viral infections that can cause PCH include measles, mumps, influenza, adenovirus,chickenpox, cytomegalovirus, and Epstein-Barr virus. Bacterial infections that can cause PCH include syphilis,Haemophilus influenzae and Mycoplasma pneumoniae. PCH can also be a side effect of some vaccinations. Chronic idiopathic(of unknown cause) PCH also occurs, but it is rare.

Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic Chronic lymphocytic leukemia, Chronic lymphocytic lymphoma, Hemolysis, Myelodysplastic syndrome, Non-hodgkin lymphoma, Primary myelofibrosis , Pulmonary small cell carcinoma
Iatrogenic Measles vaccination, Vaccinations
Infectious Disease Adenovirus, Chickenpox, Coxsackie a9, Cytomegalovirus, Epstein-barr virus, Escherichia coli, Haemophilus influenzae, Influenza, Klebsiella pneumoniae, Measles, Mumps, Mycoplasma pneumoniae, Parvovirus b19, Secondary syphilis, Tertiary syphilis, Treponema pallidum, Varicella-zoster virus , Visceral leishmaniasis
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Chronic lymphocytic leukemia, Chronic lymphocytic lymphoma, Myelodysplastic syndrome, Non-hodgkin lymphoma, Primary myelofibrosis , Pulmonary small cell carcinoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual Secondary syphilis, Tertiary syphilis
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Idiopathic

Causes in Alphabetical Order

References

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