PTF1A

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Pancreas transcription factor 1 subunit alpha is a protein that in humans is encoded by the PTF1A gene.[1][2]

Function

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.[2]

References

  1. Knöfler M, Krapp A, Hagenbüchle O, Wellauer PK (Sep 1996). "Constitutive expression of the gene for the cell-specific p48 DNA-binding subunit of pancreas transcription factor 1 in cultured cells is under control of binding sites for transcription factors Sp1 and alphaCbf". The Journal of Biological Chemistry. 271 (36): 21993–2002. doi:10.1074/jbc.271.36.21993. PMID 8703005.
  2. 2.0 2.1 "Entrez Gene: PTF1A pancreas specific transcription factor, 1a".

Further reading


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