Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene .[1] [2]
Function POP1 is a protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. This protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing.[3]
Clinical significance POP1 is also an autoantigen in patients suffering from connective tissue diseases. Mutations in the POP1 gene result in severe anauxetic dysplasia .[4]
Interactions POP1 (gene) has been shown to interact with POP4 .[5]
References
↑ Pluk H, van Eenennaam H, Rutjes SA, Pruijn GJ, van Venrooij WJ (Apr 1999). "RNA-protein interactions in the human RNase MRP ribonucleoprotein complex" . RNA . 5 (4): 512–24. doi :10.1017/S1355838299982079 . PMC 1369778 PMID 10199568 . ↑ Lygerou Z, Pluk H, van Venrooij WJ, Seraphin B (Jan 1997). "hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins" . EMBO J . 15 (21): 5936–48. PMC 452370 PMID 8918471 . ↑ "Entrez Gene: POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)" .↑ Glazov, EA; Zankl, A; Donskoi, M; Kenna, TJ; Thomas, GP; Clark, GR; Duncan, EL; Brown, MA (Mar 2011). "Whole-Exome Re-Sequencing in a Family Quartet Identifies POP1 Mutations As the Cause of a Novel Skeletal Dysplasia" . PLOS Genetics . 7 (3): e1002027. doi :10.1371/journal.pgen.1002027 . PMC 3063761 PMID 21455487 . ↑ Welting, Tim J M; van Venrooij Walther J; Pruijn Ger J M (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex" . Nucleic Acids Res . England. 32 (7): 2138–46. doi :10.1093/nar/gkh539 . PMC 407822 PMID 15096576 .
Further reading
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res . 1 (5): 223–9. doi :10.1093/dnares/1.5.223 . PMID 7584044 . Schmiedeknecht G, Büchler C, Schmitz G (1998). "A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1". Biochem. Biophys. Res. Commun . 241 (1): 59–67. doi :10.1006/bbrc.1997.7772 . PMID 9405234 . Dundr M, Olson MO (1999). "Partially processed pre-rRNA is preserved in association with processing components in nucleolus-derived foci during mitosis" . Mol. Biol. Cell . 9 (9): 2407–22. doi :10.1091/mbc.9.9.2407 . PMC 25507 PMID 9725903 . Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P." RNA . 7 (7): 937–41. doi :10.1017/S1355838201010299 . PMC 1370153 PMID 11455963 . van Eenennaam H, van der Heijden A, Janssen RJ, et al. (2002). "Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association" . Mol. Biol. Cell . 12 (11): 3680–9. doi :10.1091/mbc.12.11.3680 . PMC 60285 PMID 11694598 . Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol . 12 (1): 1–11. doi :10.1016/S0960-9822(01)00650-9 . PMID 11790298 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex" . Nucleic Acids Res . 32 (7): 2138–46. doi :10.1093/nar/gkh539 . PMC 407822 PMID 15096576 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 . PMC 514446 PMID 15302935 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . Welting TJ, Kikkert BJ, van Venrooij WJ, Pruijn GJ (2006). "Differential association of protein subunits with the human RNase MRP and RNase P complexes" . RNA . 12 (7): 1373–82. doi :10.1261/rna.2293906 . PMC 1484433 PMID 16723659 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
