PLAGL1

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Template:Infobox gene Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[1][2][3]

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[3]

Interactions

PLAGL1 has been shown to interact with P53.[4]

References

  1. Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. PMID 9722527. doi:10.1074/jbc.273.36.23026. 
  2. Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. PMC 21163Freely accessible. PMID 9671765. doi:10.1073/pnas.95.15.8835. 
  3. 3.0 3.1 "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1". 
  4. Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. PMID 11360197. doi:10.1038/sj.onc.1204298. 

Further reading


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