PKP4

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Plakophilin 4
Identifiers
Symbols PKP4 ; FLJ31261; FLJ42243; p0071
External IDs Template:OMIM5 Template:MGI HomoloGene2689
RNA expression pattern
File:PBB GE PKP4 201927 s at tn.png
File:PBB GE PKP4 201928 at tn.png
File:PBB GE PKP4 201929 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Plakophilin 4, also known as PKP4, is a human gene.[1]

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.[1]

References

  1. 1.0 1.1 "Entrez Gene: PKP4 plakophilin 4".

Further reading

  • Keil R, Wolf A, Hüttelmaier S, Hatzfeld M (2007). "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle. 6 (2): 122–7. PMID 17264675.
  • Hatzfeld M, Nachtsheim C (1997). "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins". J. Cell. Sci. 109 ( Pt 11): 2767–78. PMID 8937994.
  • Paffenholz R, Franke WW (1997). "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family". Differentiation. 61 (5): 293–304. PMID 9342840.
  • Bonné S, van Hengel J, van Roy F (1998). "Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily". Genomics. 51 (3): 452–4. doi:10.1006/geno.1998.5398. PMID 9721216.
  • Levesque G, Yu G, Nishimura M; et al. (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin". J. Neurochem. 72 (3): 999–1008. PMID 10037471.
  • Stahl B, Diehlmann A, Südhof TC (1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. PMID 10092585.
  • Deguchi M, Iizuka T, Hata Y; et al. (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
  • Schröder R, van der Ven PF, Warlo I; et al. (2001). "p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle". J. Muscle Res. Cell. Motil. 21 (6): 577–86. PMID 11206135.
  • Jaulin-Bastard F, Arsanto JP, Le Bivic A; et al. (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
  • Izawa I, Nishizawa M, Tomono Y; et al. (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. PMID 12047349.
  • Ohno H, Hirabayashi S, Iizuka T; et al. (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
  • Calkins CC, Hoepner BL, Law CM; et al. (2003). "The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein". J. Biol. Chem. 278 (3): 1774–83. doi:10.1074/jbc.M205693200. PMID 12426320.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Salomon AR, Ficarro SB, Brill LM; et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMID 12522270.
  • Hatzfeld M, Green KJ, Sauter H (2003). "Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains". J. Cell. Sci. 116 (Pt 7): 1219–33. PMID 12615965.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Setzer SV, Calkins CC, Garner J; et al. (2004). "Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration". J. Invest. Dermatol. 123 (3): 426–33. doi:10.1111/j.0022-202X.2004.23319.x. PMID 15304078.
  • Zhang Y, Wolf-Yadlin A, Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Tao WA, Wollscheid B, O'Brien R; et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
  • Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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