PCGF6

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.[1][2]

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References

  1. Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation". Genes Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. PMID 12167161.
  2. 2.0 2.1 "Entrez Gene: PCGF6 polycomb group ring finger 6".

Further reading




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