p11 protein

p11 is a protein found in the brain of humans and other mammals which has been implicated in the regulation of mood. A mouse study from 2006 found that low levels of p11 are likely to prevent the raising of serotonin levels from immediately curing clinical depression. The protein is thus a strong candidate target molecule for new antidepressant drugs.

See also

• Biochemistry
• Neuroscience

References

• Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, Yacoubi ME, Vaugeois JM, Nomikos GG, Greengard P. "Alterations in 5-HT1B receptor function by p11 in depression-like states". Science 2006;311(5757):77–80. PMID 16400147

External links

• Associated story on U.S. National Public Radio