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Osmolytes are organic compounds affecting osmosis[1]. They are soluble in the solution within a cell. They play a role in maintaining cell volume and fluid balance. For example, when a cell swells due to external osmotic pressure, membrane channels open and allow efflux of osmolytes which carry water with them, restoring normal cell volume.

Natural osmolytes include trimethylamine N-oxide (TMAO), dimethylsulfoniopropionate, trimethylglycine, and others.


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