Peanut allergy

(Redirected from Nut allergy)
Jump to navigation Jump to search
Peanut allergy
ICD-10 T78.4
ICD-9 V15.01
DiseasesDB 29154

WikiDoc Resources for Peanut allergy

Articles

Most recent articles on Peanut allergy

Most cited articles on Peanut allergy

Review articles on Peanut allergy

Articles on Peanut allergy in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Peanut allergy

Images of Peanut allergy

Photos of Peanut allergy

Podcasts & MP3s on Peanut allergy

Videos on Peanut allergy

Evidence Based Medicine

Cochrane Collaboration on Peanut allergy

Bandolier on Peanut allergy

TRIP on Peanut allergy

Clinical Trials

Ongoing Trials on Peanut allergy at Clinical Trials.gov

Trial results on Peanut allergy

Clinical Trials on Peanut allergy at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Peanut allergy

NICE Guidance on Peanut allergy

NHS PRODIGY Guidance

FDA on Peanut allergy

CDC on Peanut allergy

Books

Books on Peanut allergy

News

Peanut allergy in the news

Be alerted to news on Peanut allergy

News trends on Peanut allergy

Commentary

Blogs on Peanut allergy

Definitions

Definitions of Peanut allergy

Patient Resources / Community

Patient resources on Peanut allergy

Discussion groups on Peanut allergy

Patient Handouts on Peanut allergy

Directions to Hospitals Treating Peanut allergy

Risk calculators and risk factors for Peanut allergy

Healthcare Provider Resources

Symptoms of Peanut allergy

Causes & Risk Factors for Peanut allergy

Diagnostic studies for Peanut allergy

Treatment of Peanut allergy

Continuing Medical Education (CME)

CME Programs on Peanut allergy

International

Peanut allergy en Espanol

Peanut allergy en Francais

Business

Peanut allergy in the Marketplace

Patents on Peanut allergy

Experimental / Informatics

List of terms related to Peanut allergy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Groundnut hypersensitivity; nut allergy

Overview

Peanut allergy is a type of food allergy, distinct from nut allergies.

Pathophysiology

It is a hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which may lead to severe physical symptoms for millions of people[1].

Epidemiology and Demographics

The Asthma and Allergy Foundation of America estimates that peanut allergy is the most common cause of food-related death.[2]. Prevalence among adults and children is similar — around 1% — but at least one study shows it to be on the rise in children.[3]

Natural History, Complications and Prognosis

25% of children with a peanut allergy outgrow it.[4] It is usually treated with an exclusion diet and vigilant avoidance of foods that may be contaminated with whole peanuts or peanut particles and/or oils. The most severe peanut allergies can result in anaphylaxis[5], an emergency situation requiring immediate attention and treatment with epinephrine.

The Centers for Disease Control reported 12 to 20 food allergy deaths in 2007 [6]. Other sources put the number of deaths from assorted food allergies at approximately 125 people in the United States.[7][8]

Peanuts are the most common source of fatal allergic reactions.

Reports of death from peanut allergy in 2008 include:

  • Andrew Michael Smith (age 8) died February 2008 after he accidently came into contact with peanut allergens at home. [9]
  • Carol Kiener, (age 66) died March 2008 after suffering a severe allergic reaction to peanuts.[10]
  • Paul Anthony Thurston (age 30) died April 2008 after being served a peanut butter sandwich in jail.[11]
  • Daniel Sargent (age 30) died July 2008 after eating a cookie that had peanut butter in it at a party. [12]
  • Brian Hom II (age 18) died July 2008 after eating a dessert containing traces of peanuts while at a resort in Cabo San Lucas. [13]
  • Dexter Skinner (age 16) died July 2008 after eating a chocolate bar. [14]

The 2005 death of Christina Desforges, which was initially reported as a result of exposure to peanuts, spurred many parents to speak out about the dangers of peanut butter and jam sandwiches at schools or peanut shells on the floors of restaurants.[15] However, according to a coroner's statement in March 2006, Ms. Desforges did not die of anaphylactic shock caused by a kiss from her boyfriend after he ate a peanut butter snack, but in fact died as a result of asthma-linked respiratory failure, which was triggered by tobacco smoke at a party. Research by Jennifer Maloney suggests that peanut allergens normally leave the saliva after about an hour.[2]

Diagnosis

Symptoms

Symptoms of peanut allergy are related to the action of Immunoglobulin E (IgE) and other anaphylatoxins, which act to release histamine and other mediator substances from mast cells (degranulation). In addition to other effects, histamine induces vasodilation of arterioles and constriction of bronchioles in the lungs, also known as bronchospasm (constriction of the airways).

Symptoms can include the following:[16]

The British Dietetic Association warns that: "If untreated, anaphylactic shock can result in death due to obstruction of the upper or lower airway (bronchospasm) or hypotension and heart failure. This happens within minutes to hours of eating the peanuts. The first symptoms may include sneezing and a tingling sensation on the lips, tongue and throat followed by pallor, feeling unwell, warm and light headed. Severe reactions may return after an apparent resolution of 1-6 hours. Asthmatics with peanut sensitivity are more likely to develop life threatening reactions."[16]

Treatment

Food allergy experts at the Duke University Medical Center believe that an immunotherapy treatment for peanut allergies will be available to affected people within 5 years. [17] Immunotherapy would be used to treat a person's immune response to peanuts from an allergic reaction to a nonallergic response. This is great news for the parents of affected children and adults living with the allergy. The condition is actually becoming more common affecting about 1% of children in total. The number of affected people doubled between 1997 and 2002.[18]

Prevention

Allergen-Free Peanuts

As with most allergies, avoidance is the key. All labels for foods, medicines, cosmetics, creams, and ointments should be read. A history of allergic reactions after consuming a peanut may suggest an allergy.

While several companies have developed promising drugs to counteract peanut allergies, trials have been mired in legal battles.[19] On July 20, 2007, the North Carolina Agricultural & Technical State University announced that one of its scientists, Dr. Mohamed Ahmedna, had developed a process to make allergen-free peanuts. Initial testing showed a 100 percent inactivation of peanut allergens in whole roasted kernels, and human serums from severely allergic individuals showed no reaction when exposed to the processed peanuts. Food companies have expressed an interest in licensing the process, which purportedly does not degrade the taste or quality of treated peanuts, and even results in easier processing to use as an ingredient in food products.[20]

See also

External links

References

  1. National Institutes of Health, NIAID Allergy Statistics 2005 http://www.niaid.nih.gov/factsheets/allergystat.htm
  2. “Allergy Facts and Figures,” Asthma and Allergy Foundation of America http://www.aafa.org/display.cfm?id=9&sub=20&cont=517
  3. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: A 5-year follow-up study http://www.allerg.qc.ca/peanutallergy.htm#pressreldec903
  4. Great Ormond Street Hospital for Children NHS Trust and UCL Institute of Child Health, Peanut Allergy - Family Factsheet http://www.ich.ucl.ac.uk/factsheets/families/F000279/
  5. National Report of the Expert Panel on Food Allergy Research, NIH-NIAID 2003 http://www3.niaid.nih.gov/about/organization/dait/PDF/june30_2003.pdf
  6. Template:Cite
  7. Template:Cite
  8. Template:Cite
  9. "Boy battled peanut allergy". TriState. 2008-04-1. Check date values in: |date= (help)
  10. "Former educator, wife of ex-Sessions judge dies of allergic reaction". JohnsonCityPress.com. 2008-03-24.
  11. "Michigan Prison Inmate Dies After Eating Peanut Butter Sandwich". FoxNews.com. 2008-04-21.
  12. "Man's death a stark reminder of food allergy risks". Everett, Washington Herald. 2008-07-04.
  13. "An untimely tragedy". Evergreen Times. 2008-07-11.
  14. "Maltby youngster dies after eating chocolate". Guardian. 2008-07-11.
  15. "Nutty killer: Peanut policy perplexes parents". Hook weekly. 2006-01-05. Retrieved 2006-12-13.
  16. 16.0 16.1 The British Dietetic Association. Peanut Allergy Information for Dietitians. 1999 http://www.bda.uk.com/Downloads/peanutallergy.pdf
  17. Expert sees peanut allergy solution within 5 years - Yahoo! News
  18. Expert sees peanut allergy solution within 5 years - Yahoo! News
  19. highbeam.com
  20. North Carolina A & T State University Press Release, July 23, 2007


Template:WH Template:WS