Nucleoside phosphorylase

Jump to: navigation, search

Both purine and pyrimidine phosphorylase enzymes are done viz. the nucleotide salvage pathway. The salvage pathway is a method for the cell to produce nucleotide monophosphates when the de novo synthesis pathway has been interrupted. The de novo pathway is normally interrupted by the way of chemotherapy drugs such as methotrexate or aminopterin.

All salvage pathway enzymes require a high energy phosphate donor such as ATP or PRPP.

Adenosine uses the enzyme adenosine kinase, which is a very important enzyme in the cell. Many attempts are being made to develop an inhibitor for the enzyme in cancer chemotherapy.

See also