Nucleoside deoxyribosyltransferase

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In enzymology, a nucleoside deoxyribosyltransferase (EC 2.4.2.6) is an enzyme that catalyzes the chemical reaction

2-deoxy-D-ribosyl-base1 + base2 2-deoxy-D-ribosyl-base2 + base1

Thus, the two substrates of this enzyme are 2-deoxy-D-ribosyl-base1 and base2, whereas its two products are 2-deoxy-D-ribosyl-base2 and base1.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase. Other names in common use include purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl, transferase, deoxyribose transferase, nucleoside trans-N-deoxyribosylase, trans-deoxyribosylase, trans-N-deoxyribosylase, trans-N-glycosidase, nucleoside deoxyribosyltransferase I (purine nucleoside:purine, deoxyribosyltransferase: strictly specific for transfer between, purine bases), nucleoside deoxyribosyltransferase II [purine(pyrimidine), and nucleoside:purine(pyrimidine) deoxyribosyltransferase]. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1F8X, 1F8Y, 1S2D, 1S2G, 1S2I, 1S2L, 1S3F, 2A0K, 2F2T, 2F62, 2F64, and 2F67.

References

  • IUBMB entry for 2.4.2.6
  • BRENDA references for 2.4.2.6 (Recommended.)
  • PubMed references for 2.4.2.6
  • PubMed Central references for 2.4.2.6
  • Google Scholar references for 2.4.2.6
  • KALCKAR HM, MACNUTT WS, HOFF-JORGENSEN E (1952). "Trans-N-glycosidase studied with radioactive adenine". Biochem. J. 50: 397&ndash, 400. PMID 14915963.
  • MACNUTT WS (1952). "The enzymically catalysed transfer of the deoxyribosyl group from one purine or pyrimidine to another". Biochem. J. 50: 384&ndash, 97. PMID 14915962.
  • ROUSH AH, BETZ RF (1958). "Purification and properties of trans-N-deoxyribosylase". J. Biol. Chem. 233: 261&ndash, 6. PMID 13563482.

External links

The CAS registry number for this enzyme class is 9026-86-2.

Gene Ontology (GO) codes


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