Nitric-oxide reductase

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In enzymology, a nitric-oxide reductase (EC is an enzyme that catalyzes the chemical reaction

nitrous oxide + acceptor + H2O 2 nitric oxide + reduced acceptor

The 3 substrates of this enzyme are nitrous oxide, acceptor, and H2O, whereas its two products are nitric oxide and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with other acceptors. The systematic name of this enzyme class is nitrous-oxide:acceptor oxidoreductase (NO-forming). Other names in common use include nitrogen oxide reductase, and nitrous-oxide:(acceptor) oxidoreductase (NO-forming). This enzyme participates in nitrogen metabolism.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1EHE, 1F24, 1F25, 1F26, 1JFB, 1JFC, 1ULW, and 1XQD.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Heiss B, Frunzke K, Zumft WG (1989). "Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri". J. Bacteriol. 171: 3288&ndash, 97. PMID 2542222.

External links

The CAS registry number for this enzyme class is 37256-43-2.

Gene Ontology (GO) codes