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In a retrospective cohort study at the Mayo Clinic, researchers found that mitral valve prolapse (MVP) occurs more frequently in females but that surgery for severe mitral valve regurgitation occurs more frequently in men. In an examination of echocardiograms from 1989 through 1998, 4461 women and 3768 men were diagnosed with MVP. 52% of females and 60% of males with severe regurgitation underwent surgery (adjusted risk ratio: 0.79) and women in this category of severe regurgitation had a lower survival rate compared to men (60% vs 68% respectively, adjusted risk ratio: 1.13). Women also had lower posterior leaflet prolapsed (22% vs 31%, p<0.001), greater thickening (32% vs 28%, p<0.001), and less flail (2% vs 8%, p<0.001). Importantly, the difference in survival at 10 years was not statistically significant between women and men who underwent mitral valve surgery (77% vs 79%, p=0.14). These results suggest that the benefits in outcome arising from surgery occur for both genders. Future studies of MVP and severe mitral regurgitation should further elucdiate the gender-specific differences (Annals of Internal Medicine by Jean-Francois Avierinos et al.)
