News:Lipoprotein(a) Associated with MI

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(WikiDoc) - Researchers in Denmark have shown genetically elevated levels of lipoprotein(a) are associated with increased risk of heart attack, according to a study in JAMA. The authors are quick to note their analysis does not necessarily prove the LDL-associated lipoprotein causes MI, but that their association warrants further research. Previous studies have shown racial differences can be a major predictor of lipoprotein(a) levels. The scientists in the JAMA article examined three independent Dutch studies of white subjects from 1976 through 2007. In an accompanying editorial, Drs. George Thanassoulis and Christopher J. O'Donnel write: "These results do not provide the necessary evidence that genetic testing of the LPA locus or measurements of plasma lipoprotein(a) have a role in cardiovascular risk stratification or decisions regarding lipid-lowering therapy. Ultimately, despite nature’s best efforts to provide causal evidence for lipoprotein(a), only a true randomized controlled trial demonstrating reductions in MI with targeted lipoprotein(a)-lowering therapy can provide the evidence for benefits and risks of an lipoprotein(a)-lowering strategy.”