NAD(P)+ nucleosidase

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In enzymology, a NAD(P)+ nucleosidase (EC is an enzyme that catalyzes the chemical reaction

NAD(P)+ + H2O ADP-ribose(P) + nicotinamide

The 3 substrates of this enzyme are NAD+, NADP+, and H2O, whereas its two products are ADP-ribose and nicotinamide.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is NAD(P)+ glycohydrolase. Other names in common use include nicotinamide adenine dinucleotide (phosphate) nucleosidase, triphosphopyridine nucleotidase, NAD(P) nucleosidase, NAD(P)ase, and nicotinamide adenine dinucleotide (phosphate) glycohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
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  • ALIVISATOS SG, WOOLLEY DW (1956). "Solubilization and purification of the diphosphopyridine nucleotidase from beef spleen". J. Biol. Chem. 219: 823&ndash, 32. PMID 13319302.
  • ZATMAN LJ, KAPLAN NO, COLOWICK SP (1953). "Inhibition of spleen diphosphopyridine nucleotidase by nicotinamide, an exchange reaction". J. Biol. Chem. 200: 197&ndash, 212. PMID 13034774.
  • Zatman LJ, Kaplan NO, Colowick SP and Ciotti MM (1953). "Formation of the isonicotinic acid hydrazide analog of DPN". J. Am. Chem. Soc. 75: 3293&ndash, 3294.

External links

The CAS registry number for this enzyme class is 9025-46-1.

Gene Ontology (GO) codes