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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Soumya Sachdeva

Synonyms and Keywords: Myelophthisic anemia


Myelophthisis refers to the displacement of hemopoietic bone-marrow tissue into the peripheral blood, either by fibrosis (myelofibrosis), tumors, or granulomas. A myelophthisic blood smear is one which contains nucleated red blood cells, granulocyte precursors, and teardrop-shaped erythrocytes. This condition is also known as Myelophthisic anemia. Myelophthisis can be observed in cancers that that involve the bone marrow such as leukemia, lymphoma, and myeloma or metastatic carcinoma. The commonest cause is metastatic cancer, most often carcinomas arising in breast, lung and prostate.However any infiltrative process (e.g.,granulomatous disease) involving the marrow can produce identical findings.It should be remembered that it is also a feature of spent phase of myeloproliferative disorders.They cause marrow distortion and fibrosis which act to displace normal marrow elements and disturb mechanisms that regulate the egress of red cells and granulocytes from the marrow.

Historical Perspective




Differentiating Myelophthisis from Other Diseases

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Natural History, Complications, and Prognosis

Natural History




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| group5 = Clinical Trials Involving Myelophthisis | list5 = Ongoing Trials on Myelophthisis at Clinical Trials.govTrial results on MyelophthisisClinical Trials on Myelophthisis at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Myelophthisis | list6 = US National Guidelines Clearinghouse on MyelophthisisNICE Guidance on MyelophthisisNHS PRODIGY GuidanceFDA on MyelophthisisCDC on Myelophthisis

| group7 = Textbook Information on Myelophthisis | list7 = Books and Textbook Information on Myelophthisis

| group8 = Pharmacology Resources on Myelophthisis | list8 = AND (Dose)}} Dosing of MyelophthisisAND (drug interactions)}} Drug interactions with MyelophthisisAND (side effects)}} Side effects of MyelophthisisAND (Allergy)}} Allergic reactions to MyelophthisisAND (overdose)}} Overdose information on MyelophthisisAND (carcinogenicity)}} Carcinogenicity information on MyelophthisisAND (pregnancy)}} Myelophthisis in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Myelophthisis

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Myelophthisis | list9 = AND (pharmacogenomics)}} Genetics of MyelophthisisAND (pharmacogenomics)}} Pharmacogenomics of MyelophthisisAND (proteomics)}} Proteomics of Myelophthisis

| group10 = Newstories on Myelophthisis | list10 = Myelophthisis in the newsBe alerted to news on MyelophthisisNews trends on Myelophthisis

| group11 = Commentary on Myelophthisis | list11 = Blogs on Myelophthisis

| group12 = Patient Resources on Myelophthisis | list12 = Patient resources on MyelophthisisDiscussion groups on MyelophthisisPatient Handouts on MyelophthisisDirections to Hospitals Treating MyelophthisisRisk calculators and risk factors for Myelophthisis

| group13 = Healthcare Provider Resources on Myelophthisis | list13 = Symptoms of MyelophthisisCauses & Risk Factors for MyelophthisisDiagnostic studies for MyelophthisisTreatment of Myelophthisis

| group14 = Continuing Medical Education (CME) Programs on Myelophthisis | list14 = CME Programs on Myelophthisis

| group15 = International Resources on Myelophthisis | list15 = Myelophthisis en EspanolMyelophthisis en Francais

| group16 = Business Resources on Myelophthisis | list16 = Myelophthisis in the MarketplacePatents on Myelophthisis

| group17 = Informatics Resources on Myelophthisis | list17 = List of terms related to Myelophthisis