Multiple endocrine neoplasia type 1 physical examination

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Differentiating Multiple endocrine neoplasia type 1 from other Diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Common physical examination findings of multiple endocrine neoplasia type 1 include rash, lymphadenopathy, fever and abdominal mass.

Physical Examination

Appearance of the Patient

The general appearance of patients with multiple endocrine neoplasia type 1 range from normal appearance to obese, thin, and cachectic. Patient appearance largely depends on the manifestations of the syndrome.[1][2][3]

Vitals

Skin

  • Skin eruption of red patches with irregular borders, intact and ruptured vesicles, and crust formation

Eyes

  • Nystagmus may be present
  • Extra-ocular movements may be abnormal

Ears

  • Auditory acuity may be reduced

Neck

Abdomen

Extremities

Neurologic

  • Mental status may be altered
  • Clonus may be present

References

  1. Thakker RV (2010). "Multiple endocrine neoplasia type 1 (MEN1)". Best Pract. Res. Clin. Endocrinol. Metab. 24 (3): 355–70. doi:10.1016/j.beem.2010.07.003. PMID 20833329.
  2. Gaztambide S, Vazquez F, Castaño L (2013). "Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1)". Minerva Endocrinol. 38 (1): 17–28. PMID 23435440.
  3. Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC (1999). "Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias". Recent Prog. Horm. Res. 54: 397–438, discussion 438–9. PMID 10548885.

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