ABCC4

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Template:Infobox gene ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.[1][2]

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.[3] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.[4]

MRP4/ABCC4 expression is dysregulated in several cancers [5][6][7] and is also upregulated in peritoneal endometriosis.[8]

Interactive pathway map

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See also

References

  1. "Entrez Gene: ATP-binding cassette". 
  2. Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Research. 58 (13): 2741–7. PMID 9661885. 
  3. Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". The Journal of Clinical Investigation. 118 (8): 2747–57. PMC 2467383Freely accessible. PMID 18636120. doi:10.1172/JCI35067. 
  4. Reid G, Wielinga P, Zelcer N,van der Heijden I, Kuil A, de Haas M, et al. The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibitedby nonsteroidal antiinflammatory drugs" Proc Natl Acad Sci U S A2003;100(16) 9244-9.
  5. Ho LL, Kench JG, Handelsman DJ,Scheffer GL, Stricker PD, Grygiel JG, et al. Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer" Prostate2008;68(13) 1421-9.
  6. Copsel S, Garcia C, Diez F,Vermeulem M, Baldi A, Bianciotti LG, et al. Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation" J Biol Chem 2011;286(9) 6979-88.
  7. Holla VR, Backlund MG, Yang P,Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9.
  8. Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, CannyGO. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)" Fertil Steril 2013 Jun;99(7) 1965-73.e2. doi:10.1016/j.fertnstert.2013.01.146

Further reading

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External links

Template:ABC transporters


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