Mulder's sign

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Mulder’s Sign is a physical exam finding associated with Morton's neuroma, which may be elicited while the patient is in the supine position on the examination table. The pain of the neuroma, as well as a click, can be produced by squeezing the two metatarsal heads together with one hand, while concomitantly putting pressure on the interdigital space with the other hand. With this technique, the pain of the Morton's neuroma will be localized strictly to the plantar surface of the involved interspace, with paresthesias radiating into the affected toes.[1][2][3]


  1. Mulder, JD. "The causative mechanism in morton's metatarsalgia." J Bone Joint Surg. 1951;33B:94-95.
  2. Bencardino, et al. "Morton's Neuroma: Is It Always Symptomatic?" American Journal of Roentgenology. 2000;175(3):649-653.
  3. Waldman, Steven. "Mulder’s Sign for Morton’s Neuroma." Physical Diagnosis of Pain. Saunders, October 2005;381. ISBN 1416001123.