Molecular cellular cognition

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Key goals of studies in the field of molecular cellular cognition (MCC) include the derivation of explanations of cognitive processes that integrate molecular, cellular, and behavioral mechanisms, and finding mechanism and treatments for cognitive disorders. Although closely connected with behavioral genetics, MCC emphasizes the integration of molecular and cellular explanations of behavior, instead of focusing on the connections between genes and behavior. MCC is a field of neuroscience.

Unlike cognitive neuroscience, which historically has focused on the connection between human brain systems and behavior, the field of MCC has used model organisms such as mice to study how molecular (ie. receptor, kinase activation), intra-cellular (i.e. dendritic processes), and inter-cellular processes (i.e. synaptic plasticity; network representations such as place fields) modulate cognitive function.

Methods employed in MCC include transgenic organisms (i.e. mice), in vitro and in vivo electrophysiology, and behavioral analysis. Modeling is becoming an essential component of the field because of the complexity of the multilevel data generated

Contents 1 Scientific roots 2 Foundation of the science 3 References 4 External links 5 See also

Scientific roots

The field of MCC has its roots in the pioneering studies of the role of NMDA receptor in long-term potentiation and spatial learning. The studies that crystallized the field used knock out mice to look at the role of the alpha calcium calmodulin kinase II and fyn kinase in hippocampal long-term potentiation and spatial learning.

Foundation of the science

Molecular cellular cognition became an organized field with the formation of the Molecular Cellular Cognition Society, an organization with no membership fees and meetings that emphasize the participation of junior scientists. Its first meeting took place in Orlando, Florida on November first, 2002. As of November, 2006 the society had organized 9 meetings in North America, Europe and Asia, and included more than 1200 members.

References

• Morris RG, Anderson E, Lynch GS, Baudry M. 1986. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319:774--76
• Silva, A.J., R. Paylor, J.M. Wehner, and S. Tonegawa, Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992. 257(5067): p. 206-11.
• Silva, A.J., C.F. Stevens, S. Tonegawa, and Y. Wang, Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992. 257(5067): p. 201-6.
• Grant, S. G. N., O'Dell, J., Karl, K. A., Stein, P. L., Soriano, P. and Kandel, E. R. (1992). Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258, 1903-1910.
• Silva, A.J., Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. J Neurobiol, 2003. 54(1): p. 224-37.

External links

• Molecular and Cellular Cognition Society

See also

• Cell signaling
• Crosstalk (biology)
• Humberto Maturana
• Francisco Varela
• Santiago theory of cognition

v • d • e Neuroscience
Behavioral neurology · Cognitive neuroscience · Computational neuroscience · Molecular cellular cognition · Neural engineering · Neuroanatomy · Neurobiology · Neurochemistry · Neuroendocrinology · Neuroimaging · Neurolinguistics · Neurology · Neuromonitoring · Neuropharmacology · Neurophysiology · Neuropsychiatry · Neuropsychology · Neurosurgery · Systems neuroscience