Mezlocillin

Jump to navigation Jump to search
Mezlocillin
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • B
Routes of
administration
Intravenous, intramuscular
ATC code
Pharmacokinetic data
Protein binding16–59%
MetabolismHepatic (20–30%)
Elimination half-life1.3–4.4 hours
ExcretionRenal (50%) and biliary
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC21H25N5O8S2
Molar mass539.584 g/mol
3D model (JSmol)
  (verify)

WikiDoc Resources for Mezlocillin

Articles

Most recent articles on Mezlocillin

Most cited articles on Mezlocillin

Review articles on Mezlocillin

Articles on Mezlocillin in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Mezlocillin

Images of Mezlocillin

Photos of Mezlocillin

Podcasts & MP3s on Mezlocillin

Videos on Mezlocillin

Evidence Based Medicine

Cochrane Collaboration on Mezlocillin

Bandolier on Mezlocillin

TRIP on Mezlocillin

Clinical Trials

Ongoing Trials on Mezlocillin at Clinical Trials.gov

Trial results on Mezlocillin

Clinical Trials on Mezlocillin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Mezlocillin

NICE Guidance on Mezlocillin

NHS PRODIGY Guidance

FDA on Mezlocillin

CDC on Mezlocillin

Books

Books on Mezlocillin

News

Mezlocillin in the news

Be alerted to news on Mezlocillin

News trends on Mezlocillin

Commentary

Blogs on Mezlocillin

Definitions

Definitions of Mezlocillin

Patient Resources / Community

Patient resources on Mezlocillin

Discussion groups on Mezlocillin

Patient Handouts on Mezlocillin

Directions to Hospitals Treating Mezlocillin

Risk calculators and risk factors for Mezlocillin

Healthcare Provider Resources

Symptoms of Mezlocillin

Causes & Risk Factors for Mezlocillin

Diagnostic studies for Mezlocillin

Treatment of Mezlocillin

Continuing Medical Education (CME)

CME Programs on Mezlocillin

International

Mezlocillin en Espanol

Mezlocillin en Francais

Business

Mezlocillin in the Marketplace

Patents on Mezlocillin

Experimental / Informatics

List of terms related to Mezlocillin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending colangitis.

Mechanism of action

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

Susceptible organisms

Gram-negative

Gram-positive

External links

  • Template:DiseasesDB
  • Template:GPnotebook
  • Duke
  • Kristof R, Clusmann H, Koehler W, Fink K, Schramm J (1998). "Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange". J Neurol Neurosurg Psychiatry. 64 (3): 379–81. doi:10.1136/jnnp.64.3.379. PMC 2170014. PMID 9527154.
  • McCormick P, Greenslade L, Kibbler C, Chin J, Burroughs A, McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients". Hepatology. 25 (4): 833–6. doi:10.1002/hep.510250408. PMID 9096584.
  • Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B (1997). "Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure". Eur J Clin Pharmacol. 53 (2): 111–5. doi:10.1007/s002280050347. PMID 9403281.