Methylphenobarbital

Methylphenobarbital

Clinical data
Pregnancy category	?
Routes of administration	?
ATC code	N03AA01 (WHO)
Legal status
Legal status	US: Schedule IV
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Elimination half-life	?
Excretion	?
Identifiers
IUPAC name 5-phenyl-5-ethyl- 3-methylbarbituric acid
CAS Number	115-38-8
PubChem CID	8271
DrugBank	APRD00047
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C13H14N2O3
Molar mass	246.3

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Methylphenobarbital, also known as mephobarbital, (marketed in the US under the brand name Mebaral by Ovation) is a drug which is a barbiturate derivative.

Methylphenobarbital is used as a sedative, anxiolytic and anticonvulsant. It is the N-methylated analogue of phenobarbital, and has similar indications, therapeutic value, and tolerability.

Approval History

• 1935 Mebaral was introduced by Winthrop Pharmaceuticals.
• 2001 Methylphenobarbital discontinued in the UK.
• 2003 Mebaral acquired by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

Overdose symptoms

Symptoms of overdose of metharbital include confusion, decrease in or loss of reflexes, somnolence, pyrexia, irritability, hypothermia, poor judgment, shortness of breath or slow/troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness

References

• The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8