Malonate CoA-transferase

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In enzymology, a malonate CoA-transferase (EC is an enzyme that catalyzes the chemical reaction

acetyl-CoA + malonate acetate + malonyl-CoA

Thus, the two substrates of this enzyme are acetyl-CoA and malonate, whereas its two products are acetate and malonyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acetyl-CoA:malonate CoA-transferase. This enzyme is also called malonate coenzyme A-transferase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.


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  • HAYAISHI O (1955). "Enzymatic decarboxylation of malonic acid". J. Biol. Chem. 215: 125&ndash, 36. PMID 14392148.
  • Takamura Y and Kitayama Y (1981). "Purification and some properties of malonate decarboxylase from Pseudomonas ovalis: an oligomeric enzyme with bifunctional properties". Biochem. Int. 3: 483&ndash, 491.

External links

The CAS registry number for this enzyme class is 9026-18-0.

Gene Ontology (GO) codes