Maleylacetate reductase

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In enzymology, a maleylacetate reductase (EC is an enzyme that catalyzes the chemical reaction

3-oxoadipate + NAD(P)+ 2-maleylacetate + NAD(P)H + H+

The 3 substrates of this enzyme are 3-oxoadipate, NAD+, and NADP+, whereas its 4 products are 2-maleylacetate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxoadipate:NAD(P)+ oxidoreductase. This enzyme is also called maleolylacetate reductase. This enzyme participates in 3 metabolic pathways: gamma-hexachlorocyclohexane degradation, benzoate degradation via hydroxylation, and 1,4-dichlorobenzene degradation.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Gaal AB, Neujahr HY (1980). "Maleylacetate reductase from Trichosporon cutaneum". Biochem. J. 185: 783&ndash, 6. PMID 7387635.
  • Gaal AB and Neujahr HY (1981). "Induction of phenol-metabolizing enzymes in Trichosporon cutaneum". Arch. Microbiol. 130: 54&ndash, 58.

External links

The CAS registry number for this enzyme class is 69669-65-4.

Gene Ontology (GO) codes