Malate-CoA ligase

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In enzymology, a malate-CoA ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + malate + CoA ADP + phosphate + malyl-CoA

The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Mue S, Tuboi S and Kikuchi G (Tokyo). "On malyl-coenzyme A synthetase". J. Biochem.: 545&ndash, 551. Check date values in: |date= (help)

External links

The CAS registry number for this enzyme class is 37318-58-4.

Gene Ontology (GO) codes