MYO18B

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.[1][2][3]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[3]

References

  1. Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.
  2. Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.
  3. 3.0 3.1 "Entrez Gene: MYO18B myosin XVIIIB".

Further reading

  • Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis. 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID 12741677.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer. 112 (1): 150–4. doi:10.1002/ijc.20339. PMID 15305387.
  • Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. PMID 17294804.




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