MDN1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene.

Model organisms

Mdn1 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Heart weight	Normal
Brain histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Abnormal
All tests and analysis from

Model organisms have been used in the study of MDN1 function. A conditional knockout mouse line, called Mdn1^{tm1a(KOMP)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and three significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an increased susceptibility to bacterial infection.

Further reading

Garbarino, J. E.; Gibbons, I. R. (2002). "Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein". BMC Genomics. 3: 18. doi:10.1186/1471-2164-3-18. PMC 117441. PMID 12102729. Van De Wijngaart, D. J.; Dubbink, H. J.; Molier, M.; De Vos, C.; Trapman, J.; Jenster, G. (2009). "Functional Screening of FxxLF-Like Peptide Motifs Identifies SMARCD1/BAF60a as an Androgen Receptor Cofactor that Modulates TMPRSS2 Expression". Molecular Endocrinology. 23 (11): 1776–1786. doi:10.1210/me.2008-0280. PMID 19762545.