Lymphotactin

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chemokine (C motif) ligand 1, lymphotactin
Identifiers
SymbolXCL1
Alt. symbolsSCYC1, LTN, LPTN, ATAC, SCM-1a, SCM-1
Entrez6375
HUGO10645
OMIM600250
RefSeqNM_002995
UniProtP47992
Other data
LocusChr. 1 q24.2


Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells.[1][2] This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1.[2] XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.[3]

References

  1. Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. PMID 7602097.
  2. 2.0 2.1 Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.
  3. Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.




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