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The term Leukoencephalopathy is a broad term for leukodystrophy-like diseases (PMID 17414998). It is applied to all brain white matter diseases, whether their molecular cause is known. It can refer specifically to any of these diseases:

It can also refer to MLC1 or Megalencephalic leukoencephalopathy with subcortical cysts 1, a human gene related to the disease of the same name.