Linker of Activated T cells

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Linker of Activated T cells (LAT) is a transmembrane adapter protein associated with glycosphingolipid-enriched microdomains (GEMs)[1].

LAT was described in the early 1990s as a phosphoprotein of 36–38 kDa (pp. 36–38) rapidly phosphorylated on tyrosine residues following TCR ligation[2]. Cloning of the gene revealed that the protein product is a type III (leaderless) transmembrane protein of 262 aminoacids (long form) or 233 aminoacids (short form) in humans, 242 aminoacids in mouse, and 241 aminoacids in rat [3][4].

References

  1. Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling. Horejsi V. Immunol Lett. 2004 Mar 29;92(1-2):43-9. http://dx.doi.org/10.1016/j.imlet.2003.10.013
  2. M. Sieh, A. Batzer, J. Schlessinger and A. Weiss, GRB2 and phospholipase C-g 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol 14 (1994), pp. 4435–4442.
  3. W. Zhang, J. Sloan-Lancaster, J. Kitchen, R.P. Trible and L.E. Samelson, LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92 (1998), pp. 83–92.
  4. J.R. Weber, S. Orstavik, K.M. Torgersen, N.C. Danbolt, S.F. Berg, J.C. Ryan et al., Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med 187 (1998), pp. 1157–1161.



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