Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1gene.[1][2]
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.[2]. KATNB1 is associated with microlissencephaly.
References
↑Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID9568719.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
Toyo-Oka K, Sasaki S, Yano Y, et al. (2006). "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration". Hum. Mol. Genet. 14 (21): 3113–28. doi:10.1093/hmg/ddi339. PMID16203747.
Karabay A, Yu W, Solowska JM, et al. (2004). "Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules". J. Neurosci. 24 (25): 5778–88. doi:10.1523/JNEUROSCI.1382-04.2004. PMID15215300.
McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell Sci. 109 (3): 561–7. PMID8907702.
McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID8221885.
