Isocitrate epimerase

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In enzymology, an isocitrate epimerase (EC is an enzyme that catalyzes the chemical reaction

(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate

Hence, this enzyme has one substrate, (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate, and one product, (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on hydroxy acids and derivatives. The systematic name of this enzyme class is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase.


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  • Hoshiko S, Kunimoto Y, Arima K and Beppu T (1982). "Mechanism of L-alloisocitric acid fermentation: isocitrate epimerase activity in the cell-free-extract of Penicillium purpurogenum". Agric. Biol. Chem. 46: 143&ndash, 151.

External links

The CAS registry number for this enzyme class is 81210-68-6.

Gene Ontology (GO) codes