Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1gene.[1][2][3] Intelectin-1 functions both as a receptor for bacterial arabinogalactans[1] and for lactoferrin.[4]
Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.[5][6]
↑ 1.01.1Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (Jun 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". J Biol Chem. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID11313366.
↑Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (Feb 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi:10.1093/glycob/11.1.65. PMID11181563.
↑Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID11747454.
↑Wesener, Darryl A; Wangkanont, Kittikhun; McBride, Ryan; Song, Xuezheng; Kraft, Matthew B; Hodges, Heather L; Zarling, Lucas C; Splain, Rebecca A; Smith, David F; Cummings, Richard D; Paulson, James C; Forest, Katrina T; Kiessling, Laura L (6 July 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–610. doi:10.1038/nsmb.3053. PMC4526365. PMID26148048.
Suzuki YA, Lopez V, Lönnerdal B (2006). "Mammalian lactoferrin receptors: structure and function". Cell. Mol. Life Sci. 62 (22): 2560–75. doi:10.1007/s00018-005-5371-1. PMID16261254.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Chang BY, Peavy TR, Wardrip NJ, Hedrick JL (2004). "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins". Comp. Biochem. Physiol., Part a Mol. Integr. Physiol. 137 (1): 115–29. doi:10.1016/S1095-6433(03)00269-1. PMID14720597.
Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI (2005). "Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)". Lung Cancer. 48 (1): 19–29. doi:10.1016/j.lungcan.2004.10.011. PMID15777968.
Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C (2006). "Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue". Biochim. Biophys. Acta. 1732 (1–3): 96–102. doi:10.1016/j.bbaexp.2005.11.005. PMID16386808.
Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW (2006). "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action". Am. J. Physiol. Endocrinol. Metab. 290 (6): E1253–61. doi:10.1152/ajpendo.00572.2004. PMID16531507.
de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (2007). "Omentin plasma levels and gene expression are decreased in obesity". Diabetes. 56 (6): 1655–61. doi:10.2337/db06-1506. PMID17329619.
