Hydroxyquinol 1,2-dioxygenase

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In enzymology, a hydroxyquinol 1,2-dioxygenase (EC is an enzyme that catalyzes the chemical reaction

benzene-1,2,4-triol + O2 3-hydroxy-cis,cis-muconate

Thus, the two substrates of this enzyme are benzene-1,2,4-triol and O2, whereas its product is 3-hydroxy-cis,cis-muconate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing). This enzyme is also called hydroxyquinol dioxygenase. This enzyme participates in benzoate degradation via hydroxylation and 1,4-dichlorobenzene degradation. It employs one cofactor, iron.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TMX.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Sze IS, Dagley S (1984). "Properties of salicylate hydroxylase and hydroxyquinol 1,2-dioxygenase purified from Trichosporon cutaneum". J. Bacteriol. 159: 353&ndash, 9. PMID 6539772.

External links

The CAS registry number for this enzyme class is 91847-14-2.

Gene Ontology (GO) codes