Neutrophil elastase
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| elastase 2, neutrophil
| |
| Identifiers | |
| Symbol | ELA2 |
| Entrez | 1991 |
| HUGO | 3309 |
| OMIM | 130130 |
| RefSeq | NM_001972 |
| UniProt | P08246 |
| Other data | |
| EC number | 3.4.21.37 |
| Locus | Chr. 19 p13.3 |
Neutrophil elastase (or leukocyte elastase) is a type of enzyme that acts as a platelet activator. It consists of five exons. It is one of the two human forms of elastase.
The neutrophil form of elastase (EC 3.4.21.37) is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
Neutrophil elastase is an important protease enzyme that when expressed aberrantly can cause emphysema or emphysematous changes. This involves breakdown of the lung structure and increased airspaces.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
