Haemophilia B
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| Haemophilia B Classification and external resources | |
| ICD-10 | D67. |
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| ICD-9 | 286.1 |
| OMIM | 306900 |
| DiseasesDB | 5561 |
| MedlinePlus | 000539 |
| eMedicine | emerg/240 |
| MeSH | D002836 |
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US National Guidelines Clearinghouse on Haemophilia B NICE Guidance on Haemophilia B
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
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Haemophilia B (also spelled Hemophilia B or Hæmophilia B) is a blood clotting disorder caused by a mutation of the Factor IX gene. It is the second most common form of haemophilia, rarer than haemophilia A. It is sometimes called Christmas disease after Stephen Christmas, the first patient described with this disease.[1] In addition, the first report of its identification was published in the Christmas edition of the British Medical Journal.[2]
Treatment
Treatment (bleeding prophylaxis) is by intravenous infusion of factor IX.
Genetics
The factor IX gene is located on the X chromosome (Xq27.1-q27.2). It is inherited X-linked recessive, which explains why - as in haemophilia A - mostly males are generally affected.
Pathophysiology
Factor IX deficiency leads to an increased propensity for haemorrhage. This is in response to mild trauma or even spontaneously, such as in joints (haemarthrosis) or muscles.
References
- ↑ Christmas' disease at Who Named It
- ↑ Biggs RA, Douglas AS, MacFarlane RG, Dacie JV, Pittney WR, Merskey C, O'Brien JR. Christmas disease: a condition previously mistaken for haemophilia. Br Med J 1952;2:1378-1382. PMID 12997790.
See also
External links
- Haemophilia: What is it? at CSHL Your Genes, Your Health
- haemophilia B at GPnotebook
- Factor IX Deficiency at FPnotebook
WikiDoc Research Resources for Haemophilia B | |
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| Articles on Haemophilia B | Most recent articles on Haemophilia B • Most cited articles on Haemophilia B • Review articles on Haemophilia B • Articles on Haemophilia B in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Haemophilia B | Powerpoint slides on Haemophilia B • Images of Haemophilia B • Photos of Haemophilia B • Podcasts & MP3s on Haemophilia B • Videos on Haemophilia B |
| Evidence Based Medicine Regarding Haemophilia B | Cochrane Collaboration on Haemophilia B • Bandolier on Haemophilia B • TRIP on Haemophilia B |
| Cost Effectiveness of Haemophilia B | Cost Effectiveness of Haemophilia B |
| Clinical Trials Involving Haemophilia B | Ongoing Trials on Haemophilia B at Clinical Trials.gov • Trial results on Haemophilia B • Clinical Trials on Haemophilia B at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Haemophilia B | US National Guidelines Clearinghouse on Haemophilia B • NICE Guidance on Haemophilia B • NHS PRODIGY Guidance • FDA on Haemophilia B • CDC on Haemophilia B |
| Textbook Information on Haemophilia B | Books and Textbook Information on Haemophilia B |
| Pharmacology Resources on Haemophilia B | Dosing of Haemophilia B • Drug interactions with Haemophilia B • Side effects of Haemophilia B • Allergic reactions to Haemophilia B • Overdose information on Haemophilia B • Carcinogenicity information on Haemophilia B • Haemophilia B in pregnancy • Pharmacokinetics of Haemophilia B • |
| Genetics, Pharmacogenomics, and Proteinomics of Haemophilia B | Genetics of Haemophilia B • Pharmacogenomics of Haemophilia B • Proteomics of Haemophilia B |
| Newstories on Haemophilia B | Haemophilia B in the news • Be alerted to news on Haemophilia B • News trends on Haemophilia B |
| Commentary on Haemophilia B | Blogs on Haemophilia B |
| Patient Resources on Haemophilia B | Patient resources on Haemophilia B • Discussion groups on Haemophilia B • Patient Handouts on Haemophilia B • Directions to Hospitals Treating Haemophilia B • Risk calculators and risk factors for Haemophilia B |
| Healthcare Provider Resources on Haemophilia B | Symptoms of Haemophilia B • Causes & Risk Factors for Haemophilia B • Diagnostic studies for Haemophilia B • Treatment of Haemophilia B |
| Continuing Medical Education (CME) Programs on Haemophilia B | CME Programs on Haemophilia B |
| International Resources on Haemophilia B | Haemophilia B en Espanol • Haemophilia B en Francais |
| Business Resources on Haemophilia B | Haemophilia B in the Marketplace • Patents on Haemophilia B |
| Informatics Resources on Haemophilia B | List of terms related to Haemophilia B |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
