HLA-A66
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
major histocompatibility complex (human), class I, A66
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| Alleles | A*6601 A*6602 A*6603 | |
| Structure (See HLA-A) | ||
| Identifiers | 6601 6602 6603
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| Symbol(s) | HLA-A | |
| EBI-HLA | A*6601 | |
| EBI-HLA | A*6602 | |
| EBI-HLA | A*6603 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
Overview
HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A66 is more common in Africa and SW Europe. A66 is uncommon.
Serotype
| A*66 | A66 | A10 | A26 | Other | Sample |
| allele | % | % | % | % | size (N) |
| 6601 | 20 | 10 | 61 | 3 | 799 |
| 6602 | 38 | 10 | 4 | 31 | 205 |
| 6603 | 32 | 7 | 7 | 18 | 28 |
A*6601 Frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Cameroon Sawa | 7.7 |
| [3] | Kenya Luo | 6.8 |
| [3] | Cameroon Sawa | 7.7 |
| [3] | Cameroon Bakola Pygmy | 5.8 |
| [3] | Cameroon Baka Pygmy | 5.0 |
| [3] | Kenya Nandi | 5.0 |
| [3] | Zimbabwe Harare Shona | 0.2 |
| [3] | Cameroon Baka Pygmy | 5.0 |
| [3] | Cameroon Beti | 4.6 |
| [3] | Cameroon Bamileke | 4.5 |
| [3] | India West Bhils | 4.0 |
| [3] | Zimbabwe Harere Shona | 3.8 |
| [3] | Uganda Kampala | 3.8 |
| [3] | India Mumbia Marathas | 2.5 |
| [3] | Cape Verde Northwestern | 2.5 |
| [3] | Czech republic | 2.4 |
| [3] | Morocco Nador Metalsa | 2.1 |
| [3] | Central Portugal | 2.0 |
| [3] | India West Parsis | 2.0 |
| [3] | South Africian Natal Zulu | 2.0 |
| [3] | Kenya | 1.7 |
| [3] | Tunisia Tunis | 1.7 |
| [3] | Guinea Bissau | 1.5 |
| [3] | Georgia Tibilisi | 1.4 |
| [3] | Zambia Lusaka | 1.2 |
| [3] | Italy Bergamo | 1.1 |
| [3] | Pakistan Karachi Parsi | 1.1 |
| [3] | Oman | 0.8 |
| [3] | Sudanese | 0.8 |
| [3] | Belgium | 0.5 |
| [3] | Southeast France | 0.4 |
| [3] | Mongolia Buriat | 0.4 |
| [3] | Wales | 0.2 |
| freq | ||
| ref. | Population | (%) |
| [3] | South Africian Natal Zulu | 1.5 |
| [3] | Cameroon Yaounde | 1.1 |
| [3] | Cameroon Bamileke | 0.6 |
| [3] | Senegal Niokholo Mandenka | 0.5 |
| [3] | Kenya Nandi | 0.4 |
| [3] | Zimbabwe Harare Shona | 0.2 |
| [3] | Wales | 0.03 |
| HLA A*6603 frequencies | ||
| freq | ||
| ref. | Population | (%) |
| [3] | Cameroon Pygmy Baka | 10.0 |
| [3] | Cameroon Bakola Pygmy | 9.0 |
| [3] | Cameroon Sawa | 7.7 |
| [3] | CAR Mbenzele Pygmy | 2.8 |
| [3] | Zimbabwe Harare Shona | 0.2 |
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References
- ↑ Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. PMID 8475492.
- ↑ derived from IMGT/HLA
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in
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