HACEK organism

(Redirected from HACEK microorganisms)
Jump to navigation Jump to search

WikiDoc Resources for HACEK organism

Articles

Most recent articles on HACEK organism

Most cited articles on HACEK organism

Review articles on HACEK organism

Articles on HACEK organism in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on HACEK organism

Images of HACEK organism

Photos of HACEK organism

Podcasts & MP3s on HACEK organism

Videos on HACEK organism

Evidence Based Medicine

Cochrane Collaboration on HACEK organism

Bandolier on HACEK organism

TRIP on HACEK organism

Clinical Trials

Ongoing Trials on HACEK organism at Clinical Trials.gov

Trial results on HACEK organism

Clinical Trials on HACEK organism at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on HACEK organism

NICE Guidance on HACEK organism

NHS PRODIGY Guidance

FDA on HACEK organism

CDC on HACEK organism

Books

Books on HACEK organism

News

HACEK organism in the news

Be alerted to news on HACEK organism

News trends on HACEK organism

Commentary

Blogs on HACEK organism

Definitions

Definitions of HACEK organism

Patient Resources / Community

Patient resources on HACEK organism

Discussion groups on HACEK organism

Patient Handouts on HACEK organism

Directions to Hospitals Treating HACEK organism

Risk calculators and risk factors for HACEK organism

Healthcare Provider Resources

Symptoms of HACEK organism

Causes & Risk Factors for HACEK organism

Diagnostic studies for HACEK organism

Treatment of HACEK organism

Continuing Medical Education (CME)

CME Programs on HACEK organism

International

HACEK organism en Espanol

HACEK organism en Francais

Business

HACEK organism in the Marketplace

Patents on HACEK organism

Experimental / Informatics

List of terms related to HACEK organism

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

HACEK organisms is a group of fastidious, slow growing, pleomorphic Gram negative bacilli which form part of the oropharynx commensals and require enhanced carbon dioxide tension for recovery in culture.

Microbiology

HACEK refers to the initials of organisms including:

Pathophysiology

The pathogenesis of HACEK endocarditis is presumed to be related to colonization of the oropharynx with bacteria that gain access to the vascular space following either trauma or local infection. In addition to valvular infections in the heart, these organisms can also produce other infections such as bacteremia, abscesses, peritonitis, otitis media, conjunctivitis, pneumonia, peritonitis, arthritis and osteomyelitis, and periodontal infections.

Epidemiology and Demographics

HACEK organisms account for about 3% of cases of endocarditis,[2] with an insidious onset and subacute course. They are the most common Gram negative casue of endocarditis among patients who do not use intravenous drugs. Most patients with HACEK endocarditis have preexisting cardiac defects or prior dental manipulations. The duration of symptoms prior to diagnosis is reported to be longer than 2 weeks but shorter than 6 months.[3]

Diagnosis

Laboratory Studies

Given the fastidious growth requirements, HACEK bacteria are a recognized cause of culture-negative endocarditis. The organisms can be identified after subculture on 5 to 8% sheep blood and chocolate agar at 35 to 37°C for 48 to 72 hours in an aerobic atmosphere containing 5 to 10% CO2.[4] Although the mean duration for incubation of blood cultures until detection of growth is 3 to 5 days, up to 30 days may be required. Biochemical properties are used to differentiate members of the HACEK group. However, biopatterns may be varied by inoculum volume and growth conditions, which prompts the utilization of molecular techniques such as 16S rRNA sequencing.[5][6][7]

Treatment

The treatment of endocarditis caused by HACEK organisms should be based on antimicrobial susceptibility tests, including tests for β-lactamase ctivity. Since many of these organisms are slow growing, such tests can be problematic. Although there are limited published clinical data demonstrating the efficacy of ceftriaxone or ampicillin-sulbactam therapy, these drugs should be considered the regimens of choice for the treatment of patients with HACEK endocarditis.[8] Fluoroquinolones should be considered as an alternative agent for patients unable to tolerate β-lactam therapy. The American Heart Association recommends that native-valve and prosthetic-valve endocarditis be treated for 4 weeks and 6 weeks, respectively.[9] HACEK endocarditis is associated with a favorable prognosis, with a cure rate of 82 to 87% of patients with medical treatment alone or associated with surgery.[10]

References

  1. 1.0 1.1 Nørskov-Lauritsen N, Kilian M (2006). "Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates". Int. J. Syst. Evol. Microbiol. 56 (Pt 9): 2135–46. doi:10.1099/ijs.0.64207-0. PMID 16957111. Unknown parameter |month= ignored (help)
  2. Steckelberg JM, Melton LJ, Ilstrup DM, Rouse MS, Wilson WR (1990). "Influence of referral bias on the apparent clinical spectrum of infective endocarditis". Am. J. Med. 88 (6): 582–8. PMID 2346159. Unknown parameter |month= ignored (help)
  3. Das M, Badley AD, Cockerill FR, Steckelberg JM, Wilson WR (1997). "Infective endocarditis caused by HACEK microorganisms". Annu. Rev. Med. 48: 25–33. doi:10.1146/annurev.med.48.1.25. PMID 9046942.
  4. Brouqui P, Raoult D (2001). "Endocarditis due to rare and fastidious bacteria". Clin. Microbiol. Rev. 14 (1): 177–207. doi:10.1128/CMR.14.1.177-207.2001. PMC 88969. PMID 11148009. Unknown parameter |month= ignored (help)
  5. Das I, DeGiovanni JV, Gray J (1997). "Endocarditis caused by Haemophilus parainfluenzae identified by 16S ribosomal RNA sequencing". J. Clin. Pathol. 50 (1): 72–4. PMC 499719. PMID 9059363. Unknown parameter |month= ignored (help)
  6. Hamed KA, Dormitzer PR, Su CK, Relman DA (1994). "Haemophilus parainfluenzae endocarditis: application of a molecular approach for identification of pathogenic bacterial species". Clin. Infect. Dis. 19 (4): 677–83. PMID 7528552. Unknown parameter |month= ignored (help)
  7. Wormser GP, Bottone EJ, Tudy J, Hirschman SZ (1978). "Case report. Cardiobacterium hominis: review of prior infections and report of endocarditis on a fascia lata prosthetic heart valve". Am. J. Med. Sci. 276 (1): 117–26. PMID 727215.
  8. Francioli PB (1993). "Ceftriaxone and outpatient treatment of infective endocarditis". Infect. Dis. Clin. North Am. 7 (1): 97–115. PMID 8463657. Unknown parameter |month= ignored (help)
  9. Baddour LM, Wilson WR, Bayer AS; et al. (2005). "Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America". Circulation. 111 (23): e394–434. doi:10.1161/CIRCULATIONAHA.105.165564. PMID 15956145. Unknown parameter |month= ignored (help)
  10. Berbari EF, Cockerill FR, Steckelberg JM (1997). "Infective endocarditis due to unusual or fastidious microorganisms". Mayo Clin. Proc. 72 (6): 532–42. doi:10.1016/S0025-6196(11)63302-8. PMID 9179137. Unknown parameter |month= ignored (help)

Template:Bacterial diseases