Glycerophosphocholine cholinephosphodiesterase

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In enzymology, a glycerophosphocholine cholinephosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

sn-glycero-3-phosphocholine + H2O glycerol + choline phosphate

Thus, the two substrates of this enzyme are sn-glycero-3-phosphocholine and H2O, whereas its two products are glycerol and choline phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is sn-glycero-3-phosphocholine cholinephosphohydrolase. This enzyme is also called L-3-glycerylphosphinicocholine cholinephosphohydrolase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WRA.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Abra RM, Quinn PJ (1975). "A novel pathway for phosphatidylcholine catabolism in rat brain homogenates". Biochim. Biophys. Acta. 380: 436&ndash, 41. PMID 166661.

External links

The CAS registry number for this enzyme class is 60063-78-7.

Gene Ontology (GO) codes