Gastricsin

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Gastricsin also known as pepsinogen C is an enzyme that in humans is encoded by the PGC gene.[1][2][3][4]

Function

Gastricsin is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.[4]

Clinical significance

Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.[4]

See also

References

  1. Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K (January 1988). "Primary structure of human pepsinogen C gene". J. Biol. Chem. 263 (3): 1382–5. PMID 3335549.
  2. Pals G, Azuma T, Mohandas TK, Bell GI, Bacon J, Samloff IM, Walz DA, Barr PJ, Taggart RT (February 1989). "Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter". Genomics. 4 (2): 137–48. doi:10.1016/0888-7543(89)90292-9. PMID 2567697.
  3. Taggart RT, Cass LG, Mohandas TK, Derby P, Barr PJ, Pals G, Bell GI (January 1989). "Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A". J. Biol. Chem. 264 (1): 375–9. PMID 2909526.
  4. 4.0 4.1 4.2 "Entrez Gene: PGC progastricsin (pepsinogen C)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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