Gallbladder adenocarcinoma
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Gallbladder adenocarcinoma Classification and external resources | |
| ICD-10 | C23–C24 |
|---|---|
| ICD-9 | 156 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Gallbladder adenocarcinoma is overall uncommon, but the most common primary hepatobiliary carcinoma and the fifth most common malignancy of the GI tract.
Over 85 out of every 100 gallbladder cancers (85%) are adenocarcinomas. There are three types of adenocarcinomas:
- Non papillary adenocarcinoma
- Papillary adenocarcinoma
- Mucinous adenocarcinoma
More than 75 out of every 100 gallbladder cancers (75%) are non-papillary adenocarcinomas.
Only about 6 out of every 100 diagnosed gallbladder cancers (6%) are papillary adenocarcinomas. These develop in the tissues that hold the gallbladder in place (connective tissues). This type of gallbladder cancer is less likely to spread to the liver and nearby lymph nodes. It tends to have a better outlook than most other types of gallbladder cancer.
With mucinous adenocarcinomas, the cancer cells are often in pools of mucus, which is how the cancer gets its name. Only about 1 or 2 out of every 100 gallbladder cancers (1 or 2%) are mucinous adenocarcinomas.
Demographics
Gallbladder adenocarcinoma predominantly affects older persons with long-standing cholecystolithiasis.
Risk Factors
- Age
- Gallstones and gallbladder inflammation
- Family history
- Porcelain gallbladder
- Cigarette smoking and other chemicals
- Abnormalities of the pancreas and bile duct
- Gallbladder polyps
- Obesity
- Diet
- Race
- Typhoid
- Hormone replacement therapy
Diagnosis
 CT: Gallbladder adenocarcinoma |
 CT: Gallbladder adenocarcinoma |
 CT: Gallbladder adenocarcinoma |
 CT: Gallbladder adenocarcinoma |
 CT: Gallbladder adenocarcinoma |
Case Example
 69 year old women with two month history of right upper quadrant pain . Large heterogenous, hypovascular liver mass which abuts an abnormal - appearing gallbladder |
 Diagnostic considerations here would include, first, a locally invasive gallbladder adenocarcinoma and second, an occult colon carcinoma. |
 Cholangiocarcinoma is considered less likely due to the lack of biliary obstruction. |
 Adenopathies |
 3.5 cm simple cyst associated with the upper pole of the right kidney. |
Differential Diagnosis
Squamous cell gallbladder cancer
Squamous cell cancers develop from the skin-like cells that form the lining of the gallbladder, along with the gland cells. Doctors treat these cancers in the same way as adenocarcinomas.
Adenosquamous gallbladder cancer
Adenosquamous carcinomas are cancers that have both squamous cancer cells and glandular cancer cells. Your doctor may call this a 'mixed histology'. Doctors treat these cancers in the same way as adenocarcinomas.
Small cell cancer of the gallbladder
Small cell carcinomas are also called oat cell carcinomas. They are called this because the cancer cells are a distinctive oat shape.
Gallbladder sarcomas
Sarcoma is the name for a cancer that affects the supportive or protecting tissues of the body – also called the connective tissues. Muscles, blood vessels and nerves are all connective tissues. A cancer that begins in the muscle layer of the gallbladder is a sarcoma.
Histopathological Findings
 Gallbladder adenocarcinoma histopathology |
 Gallbladder adenocarcinoma: Lymphatic invasion histopathology |
See Also
Additional Resources
External Links
- Gallbladder adenocarcinoma case examples
- Gallbladder adenocarcinoma at Virtual Pathology Museum
- Gallbladder carcinoma at e-medicine
- Gallbladder tumors at e-medicine
- Well-differentiated adenocarcinoma of the gallbladder mimicking minimal deviation adenocarcinoma of the cervix: Case report
- Adenocarcinoma of the gallbladder--a 5 year review of outcome in Newcastle upon Tyne
- Aggressive adenocarcinoma of gallbladder with distant metastases and venous thrombosis at initial presentation
- A human gallbladder adenocarcinoma cell line
Symptoms and signs (R00-R69, 780-789) |
|
|---|---|
| Circulatory and respiratory systems |
Tachycardia - Bradycardia - Palpitation - Heart murmur - Nosebleed - Hemoptysis - Cough - abnormalities of breathing (Dyspnea, Orthopnoea, Stridor, Wheeze, Cheyne-Stokes respiration, Hyperventilation, Mouth breathing, Hiccup, Bradypnea, Hypoventilation) - Chest pain - Asphyxia - Pleurisy - Respiratory arrest - Sputum - Bruit |
| Digestive system and abdomen | Abdominal pain - Acute abdomen - Nausea - Vomiting - Heartburn - Dysphagia - Flatulence - Burping - Fecal incontinence - Encopresis - Hepatomegaly - Splenomegaly - Hepatosplenomegaly - Jaundice - Ascites - Fecal occult blood - Halitosis |
| Skin and subcutaneous tissue | disturbances of skin sensation (Hypoesthesia, Paresthesia, Hyperesthesia) - Rash - Cyanosis - Pallor - Flushing - Petechia - Desquamation - Induration |
| Nervous and musculoskeletal systems |
abnormal involuntary movements (Tremor, Spasm, Fasciculation, Athetosis) - Gait abnormality - lack of coordination (Ataxia, Dysmetria, Dysdiadochokinesia, Hypotonia) - Tetany - Meningism - Hyperreflexia |
| Urinary system | Dysuria - Vesical tenesmus - Urinary incontinence - Urinary retention - Oliguria - Polyuria - Nocturia |
| Cognition, perception, emotional state and behaviour |
Anxiety - Somnolence - Coma - Amnesia (Anterograde amnesia, Retrograde amnesia) - Dizziness/Vertigo - smell and taste (Anosmia, Ageusia, Parosmia, Parageusia) |
| Speech and voice | speech disturbances (Dysphasia, Aphasia, Dysarthria) - symbolic dysfunctions (Dyslexia, Alexia, Agnosia, Apraxia, Acalculia, Agraphia) - voice disturbances (Dysphonia, Aphonia) |
| General symptoms and signs | Fever (Hyperpyrexia) - Headache - Chronic pain - Malaise - Fatigue - Fainting (Vasovagal syncope) - Febrile seizure - Shock (Cardiogenic shock) - Lymphadenopathy - Edema (Peripheral edema, Anasarca) - Hyperhidrosis (Sleep hyperhidrosis) - Delayed milestone - Failure to thrive - food and fluid intake (Anorexia, Polydipsia, Polyphagia) - Cachexia - Xerostomia - Clubbing |
WikiDoc Research Resources for Gallbladder adenocarcinoma | |
|---|---|
| Articles on Gallbladder adenocarcinoma | Most recent articles on Gallbladder adenocarcinoma • Most cited articles on Gallbladder adenocarcinoma • Review articles on Gallbladder adenocarcinoma • Articles on Gallbladder adenocarcinoma in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Gallbladder adenocarcinoma | Powerpoint slides on Gallbladder adenocarcinoma • Images of Gallbladder adenocarcinoma • Photos of Gallbladder adenocarcinoma • Podcasts & MP3s on Gallbladder adenocarcinoma • Videos on Gallbladder adenocarcinoma |
| Evidence Based Medicine Regarding Gallbladder adenocarcinoma | Cochrane Collaboration on Gallbladder adenocarcinoma • Bandolier on Gallbladder adenocarcinoma • TRIP on Gallbladder adenocarcinoma |
| Cost Effectiveness of Gallbladder adenocarcinoma | Cost Effectiveness of Gallbladder adenocarcinoma |
| Clinical Trials Involving Gallbladder adenocarcinoma | Ongoing Trials on Gallbladder adenocarcinoma at Clinical Trials.gov • Trial results on Gallbladder adenocarcinoma • Clinical Trials on Gallbladder adenocarcinoma at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Gallbladder adenocarcinoma | US National Guidelines Clearinghouse on Gallbladder adenocarcinoma • NICE Guidance on Gallbladder adenocarcinoma • NHS PRODIGY Guidance • FDA on Gallbladder adenocarcinoma • CDC on Gallbladder adenocarcinoma |
| Textbook Information on Gallbladder adenocarcinoma | Books and Textbook Information on Gallbladder adenocarcinoma |
| Pharmacology Resources on Gallbladder adenocarcinoma | Dosing of Gallbladder adenocarcinoma • Drug interactions with Gallbladder adenocarcinoma • Side effects of Gallbladder adenocarcinoma • Allergic reactions to Gallbladder adenocarcinoma • Overdose information on Gallbladder adenocarcinoma • Carcinogenicity information on Gallbladder adenocarcinoma • Gallbladder adenocarcinoma in pregnancy • Pharmacokinetics of Gallbladder adenocarcinoma • |
| Genetics, Pharmacogenomics, and Proteinomics of Gallbladder adenocarcinoma | Genetics of Gallbladder adenocarcinoma • Pharmacogenomics of Gallbladder adenocarcinoma • Proteomics of Gallbladder adenocarcinoma |
| Newstories on Gallbladder adenocarcinoma | Gallbladder adenocarcinoma in the news • Be alerted to news on Gallbladder adenocarcinoma • News trends on Gallbladder adenocarcinoma |
| Commentary on Gallbladder adenocarcinoma | Blogs on Gallbladder adenocarcinoma |
| Patient Resources on Gallbladder adenocarcinoma | Patient resources on Gallbladder adenocarcinoma • Discussion groups on Gallbladder adenocarcinoma • Patient Handouts on Gallbladder adenocarcinoma • Directions to Hospitals Treating Gallbladder adenocarcinoma • Risk calculators and risk factors for Gallbladder adenocarcinoma |
| Healthcare Provider Resources on Gallbladder adenocarcinoma | Symptoms of Gallbladder adenocarcinoma • Causes & Risk Factors for Gallbladder adenocarcinoma • Diagnostic studies for Gallbladder adenocarcinoma • Treatment of Gallbladder adenocarcinoma |
| Continuing Medical Education (CME) Programs on Gallbladder adenocarcinoma | CME Programs on Gallbladder adenocarcinoma |
| International Resources on Gallbladder adenocarcinoma | Gallbladder adenocarcinoma en Espanol • Gallbladder adenocarcinoma en Francais |
| Business Resources on Gallbladder adenocarcinoma | Gallbladder adenocarcinoma in the Marketplace • Patents on Gallbladder adenocarcinoma |
| Informatics Resources on Gallbladder adenocarcinoma | List of terms related to Gallbladder adenocarcinoma |
| ||||
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
