G-protein coupled receptor kinases

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G-Protein coupled receptor kinases (GRKs), regulate the activity of G-protein coupled receptors by phosphorylating their intracellular domains after their associated G-proteins have been released and activated.

The phosphorylated serines and threonine residues act as binding sites for Arrestin proteins which prevent the reassociation of the G-proteins with their receptors, thereby preventing reactivation of the signaling pathway.

Types

Name Notes OMIM Gene
G-protein coupled receptor kinase 1 #1 is rhodopsin kinase 180381 GRK1
G-protein coupled receptor kinase 2 (BARK1) #2 is beta adrenergic receptor kinase-1 109635 ADRBK1
G-protein coupled receptor kinase 3 (BARK2) beta adrenergic receptor kinase-2 109636 ADRBK2
G-protein coupled receptor kinase 4 #4 has been associated with regulation of kidney tubule function 137026 GRK4
G-protein coupled receptor kinase 5 Transgenic mice lacking #5 have altered core body temperature 600870 GRK5
G-protein coupled receptor kinase 6 Transgenic mice lacking #6 have altered response to leukotriene B4 600869 GRK6

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