FMNL2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[1][2]

Expression

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[1] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[3]) is regulated through autoinhibition, and may become activated through Rho proteins.[4] The FMNL2 gene is expressed in multiple human tissues.[5]

Function

Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[1]

Clinical significance

FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[6]

See also

References

  1. 1.0 1.1 1.2 "Entrez Gene: FMNL2 formin-like 2".
  2. Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
  3. "formin-like protein 2 [Homo sapiens]" (NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC". Oncogene. 29 (16): 2441–8. doi:10.1038/onc.2009.515. PMID 20101212.
  5. Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O (2010). "Characterization of Diaphanous-related formin FMNL2 in human tissues". BMC Cell Biol. 11: 55. doi:10.1186/1471-2121-11-55. PMC 2912821. PMID 20633255.
  6. Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis. 23 (11): 1041–7. doi:10.1007/s00384-008-0520-2. PMID 18665374.