FHOD1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene.[1][2][3]

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.[3]

Interactions

FHOD1 has been shown to interact with RAC1.[4]

References

  1. Westendorf JJ, Mernaugh R, Hiebert SW (Jul 1999). "Identification and characterization of a protein containing formin homology (FH1/FH2) domains". Gene. 232 (2): 173–82. doi:10.1016/S0378-1119(99)00127-4. PMID 10352228.
  2. Boehm MB, Milius TJ, Zhou Y, Westendorf JJ, Koka S (Aug 2005). "The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway". Biochem Biophys Res Commun. 335 (4): 1090–4. doi:10.1016/j.bbrc.2005.07.191. PMID 16112087.
  3. 3.0 3.1 "Entrez Gene: FHOD1 formin homology 2 domain containing 1".
  4. Westendorf, J J (Dec 2001). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element". J. Biol. Chem. United States. 276 (49): 46453–9. doi:10.1074/jbc.M105162200. ISSN 0021-9258. PMID 11590143.

Further reading




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